Title: Insufficient Maintenance Dna Methylation Is Associated with Abnormal Embryonic Development
نویسندگان
چکیده
Li-Jun Yin ([email protected]) Yu Zhang ([email protected]) Ping-Ping Lv ([email protected]) Wei-Hua He ([email protected]) Yan-Ting Wu ([email protected]) Ai-Xia Liu ([email protected]) Guo-Lian Ding ([email protected]) Fan Qu ([email protected]) Chen-Ming Xu ([email protected]) Min-Yue Dong ([email protected]) Xiao-Ming Zhu ([email protected]) He-Feng Huang ([email protected])
منابع مشابه
Insufficient maintenance DNA methylation is associated with abnormal embryonic development
BACKGROUND Early pregnancy loss (EPL) is a frustrating clinical problem, whose mechanisms are not completely understood. DNA methylation, which includes maintenance methylation and de novo methylation directed by DNA methyltransferases (DNMTs), is important for embryo development. Abnormal function of these DNMTs may have serious consequences for embryonic development. METHODS To evaluate the...
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Background Genomic imprinting is a heritable and developmentally essential phenomenon by which gene expression occurs in an allele-specific manner1. While the imprinted alleles are primarily silenced by DNA methylation, it remains largely unknown how methylation is targeted to imprinting control region (ICR), also called differentially methylated region (DMR), and maintained. Here we show that ...
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Background: In somatic cell nuclear transfer (SCNT) method of cloning, transferred nucleus should be dedifferentiated from differentiated state to embryonic state. Molecular analysis showed that the reprogramming in the transferred nucleus was incomplete and cloned embryos have epigenetic abnormalities such as high DNA methylations levels. Since methylation in pre-implantation embryos has a cri...
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Maternal-effect mutations in NLRP7 cause rare biparentally inherited hydatidiform moles (BiHMs), abnormal pregnancies containing hypertrophic vesicular trophoblast but no embryo. BiHM trophoblasts display abnormal DNA methylation patterns affecting maternally methylated germline differentially methylated regions (gDMRs), suggesting that NLRP7 plays an important role in reprogramming imprinted g...
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